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Adrià Mitjavila Ventura
MSc | Bioinformatician at Institut Josep Carreras
Biotechnologist with training in Molecular Genetics and Bioinformatics. Interested in omics data analysis to study the mechanisms of gene regulation in mammals. See more about me on my website.
Experience
PhD student
Institut Germans Trias i Pujol & Institut Josep Carreras
Badalona, Spain
11/2022 - Present
Group of Regulatory Genomics (Dr. Tanya Vavouri)
Study of the role of transposable elements in the evolution of gene regulation in mammals.
Bioinformatician & master’s thesis student
Badalona, Spain
08/2021 - 11/2022
Group of Regulatory Genomics (Dr. Tanya Vavouri)
Study of Piwi-interacting RNAs (piRNAs), their biogenesis mechanisms and their conservation across species.
- Analysis and integration of small RNA-seq, RNA-seq and genomic data.
- Development of a method for differential expression without gene length differences when using multiple species.
- Mentoring of bachelor’s and master’s thesis students.
- Master’s thesis (UOC): Analysis of the variation in piRNA expression across three Mus species.
Bioinformatician
Milan, Italy
07/2019 - 07/2021
Group of Epigenetic Mechanisms in Cancer (Dr. Diego Pasini)
Study of Wnt/\(\beta\)catenin signaling pathway -and others- and its effects in transcription and epigenetic modifications in the context of colorectal cancer and stem cell development.
- Analysis and integration of omics data (RNA-/ChIP-/ATAC-seq).
- Comparison of different ATAC-seq peak callers.
- Comparison of different sequencing depths for RNA-seq and their influence in differential expression analysis.
Master’s thesis student & Research assistant
Instituto de Biomedicina de Sevilla
Seville, Spain
09/2017 - 10/2018
Group of Gene Expression (Dr. Sebastián Chávez)
Study of Xrn1 and Ccr4 roles in yeast nucleosome architecture and gene transcription.
- Analysis of MNase-seq data from Xrn1-, Ccr4-mutant and WT yeast strains.
- Perform MNase-qPCR experiments, including MNase DNA digestion, primer desing, qPCRs and analysis.
- Master’s thesis (US): Influence of Xrn1 in nucleosome positioning […] and its effects in transcription.
Internship student
Institut d’Investigació Biomèdica de Girona
Girona, Spain
07/2017 - 09/2017
Unit of Diabetes, Endocrinology and Nutrition
Extracurricular internship. Identification of novel factors (genetic and bacterial) related to adipose tissue physiology and obesity.
- RNA extraction from mouse hepatic biopsies.
- DNA extraction from human feces to study the composition of the microbiota.
Internship & bachelor’s thesis student
Microbial. Sistemes i aplicacions analítiques, S.L.
Girona, Spain
09/2016 - 06/2017
Microbiological and molecular analyses of food and water for pathogen detection and food forensics | Study of butyrate effects on the ileal microbiota of colectomized colorectal cancer patients.
- DNA extraction of intestinal mucosa biopsies.
- (q)PCR experiments to detect clusters and families of bacteria.
- NGS data analysis to quantify bacterial genera in intestinal biopsies.
- Bachelor’s thesis (UdG): Butyrate-induced changes in the […] microbiota in colorectal cancer patients […].
Education
PhD in Bioinformatics
Universitat Autònoma de Barcelona (UAB)
Barcelona, Spain
2022 - Present
- INPhINIT Incoming PhD Fellowship from LaCaixa.
- Research carried out at Regulatory Genomics group of the Institut Josep Carreras (IJC).
MSc in Bioinformatics and Biostatistics
Universitat Oberta de Catalunya (UOC)
Online
2018 - 2022
- Focused on Computational Genomics.
- Master’s thesis: Analysis of the variation in piRNA expression across three close related Mus species. Grade: 9.7/10 (with honours). Supervisor: Dr. Tanya Vavouri
- Overall grade: 8.94/10.
MSc in Molecular Genetics and Biotechnology
Universidad de Sevilla (US)
Seville, Spain
2017 - 2018
- Specialization in Molecular Biology Research.
- Master’s thesis: Influence of Xrn1 in nucleosome positioning across Saccharomyces cerevisiae genome and its effects in transcription. Grade: 9.2/10. Supervisors: Dr. Sebastián Chávez de Diego & Dr. Gabriel Gutiérrez Pozo.
- Overall grade: 9.33/10.
BSc in Biotechnology
Universitat de Girona (UdG)
Girona, Spain
2012 - 2017
- Specialization in Cellular & Molecular Biotechnology.
- Bachelor’s thesis: Butyrate-induced changes in the diversity of intestinal mucosa-associated microbiota in colorectal cancer patients submitted to a lateral ileostomy. Grade: 9.4/10. Supervisor: Prof. Jesús García-Gil
- Overall grade: 8.12/10.
Publications
Begley et al. Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration. RNA Biology. 2021. doi: 10.1080/15476286.2020.1845504
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Posters & presentations
Mitjavila & Vavouri. Analysis of piRNA variation across three Mus species (in Catalan). Oral presentation at the Jornades de Biologia de la Reproducció from the Catalan Society of Biology (March 2022)
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